Abstract | INTRODUCTION: MATERIALS AND METHODS: A total of 245 patients received postoperative treatment with 75 mg or 150 mg diclofenac p.o. daily for 14 days. RESULTS: Patients who received 75 mg diclofenac per day needed paracetamol as an additional analgesic significantly more often (p=0.0162) than patients who were treated with 150 mg diclofenac daily (75 mg twice a day). The incidence of adverse gastrointestinal events was significantly lower in the group receiving 75 mg diclofenac daily than in the group receiving the higher dose (23.1% vs 37.1%; p=0.025). Six months after the operation, no differences were observed between the two groups with regard to pain or functionality measured in terms of overall mobility of the hip. No patient of either group developed clinically relevant heterotopic ossifications. CONCLUSION:
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Authors | Martin Handel, Oliver Phillips, Sven Anders, Franz Xaver Köck, Stefan Sell |
Journal | Archives of orthopaedic and trauma surgery
(Arch Orthop Trauma Surg)
Vol. 124
Issue 7
Pg. 483-5
(Sep 2004)
ISSN: 0936-8051 [Print] Germany |
PMID | 15205987
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Cholestyramine Resin
- Diclofenac
- Acetaminophen
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Topics |
- Acetaminophen
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Analgesics, Non-Narcotic
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Arthroplasty, Replacement, Hip
- Cholestyramine Resin
(administration & dosage)
- Diclofenac
(administration & dosage)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Gastrointestinal Tract
(drug effects)
- Humans
- Male
- Middle Aged
- Ossification, Heterotopic
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Prospective Studies
- Treatment Outcome
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