Abstract | OBJECTIVE: METHODS AND RESULTS: Mice deficient in both LDLr and murine HL, alone or transgenically expressing similar levels of either human HL or ciHL, were fed a high-fat, cholesterol-enriched "Western" diet for 3 months to accelerate the development of atherosclerosis. Levels of plasma lipids, insulin, glucose, and liver enzymes were measured monthly, and aortic atherosclerosis was quantitated after 3 months. Plasma insulin, glucose, and liver enzyme levels did not differ significantly from controls. After 3 months, expression of HL reduced plasma cholesterol by 55% to 65% and reduced atherosclerosis by 40%. Surprisingly, expression of ciHL did not reduce plasma cholesterol or atherosclerosis. CONCLUSIONS:
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Authors | Helén L Dichek, Kun Qian, Nalini Agrawal |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 24
Issue 9
Pg. 1696-702
(Sep 2004)
ISSN: 1524-4636 [Electronic] United States |
PMID | 15205216
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins
- Blood Glucose
- Insulin
- LIPC protein, human
- Lipoproteins
- Receptors, LDL
- Triglycerides
- Cholesterol
- Lipase
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Topics |
- Animals
- Apolipoproteins
(blood)
- Arteriosclerosis
(blood, enzymology, genetics)
- Blood Glucose
(analysis)
- Catalysis
- Cholesterol
(blood)
- Crosses, Genetic
- Diet, Atherogenic
- Female
- Humans
- Insulin
(blood)
- Lipase
(deficiency, genetics, physiology)
- Lipoproteins
(blood)
- Liver
(chemistry, enzymology, ultrastructure)
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Receptors, LDL
(deficiency, genetics)
- Triglycerides
(analysis)
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