Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity.

Abstract	Some of the signaling phenotypic abnormalities observed in peripheral blood T cells from patients with systemic lupus erythematosus resemble those seen in cells anergized by stimulation through the TCR/CD3 complex, in the absence of costimulatory signals, or by stimulation with altered ligands. The potential association of this "anergic" phenotype and the triggering of autoimmune responses in human lupus is discussed.
Authors	Ana M Blasini, Martín A Rodríguez
Journal	International reviews of immunology (Int Rev Immunol) 2004 May-Aug Vol. 23 Issue 3-4 Pg. 265-72 ISSN: 0883-0185 [Print] England
PMID	15204088 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Receptor-CD3 Complex, Antigen, T-Cell
Topics	Autoimmunity Clonal Anergy Humans Lupus Erythematosus, Systemic (immunology) Membrane Microdomains (physiology) Receptor-CD3 Complex, Antigen, T-Cell (metabolism) Signal Transduction T-Lymphocytes (chemistry, immunology)

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