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Effects of aluminum speciation on murine neuroblastoma cells.

Abstract
Murine neuroblastoma cells behave differently in the presence of Al(acac)3 [acac = 2,4-pentanedionate; acetylacetonate] or Al(malt)3 [malt = 3-hydroxy, 2-methyl, 4-pyronate; maltolate] with respect to Al(lac)3 [lac = 2-hydroxypropionate; lactate]. Thus, a remarkable cytotoxic effect was observed in the first case; on the contrary, an evident cytostatic and neuritogenic effect was produced by aqueous Al(lac)3. The hydrolytically stable complexes Al(acac)3 and Al(malt)3 were both toxic in the concentration range of 0.10-0.30 and 0.10-0.50 mM, respectively, over 24 h. In contrast with this behavior Al(lac)3 displayed a potent cytostatic activity with induction of neurites at 0.2-10 mM. Al(OH)3 manifested biological effects comparable to those exhibited by Al(lac)3. AlPO4 was also cytostatic and led to a morphological differentiation of the neuroblastoma cells, qualitatively different from that elicited by Al(lac)3. The morphological effects induced by Al(lac)3, Al(OH)3, and AlPO4 were irreversible.
AuthorsP Zatta, M Perazzolo, L Facci, S D Skaper, B Corain, M Favarato
JournalMolecular and chemical neuropathology (Mol Chem Neuropathol) 1992 Feb-Apr Vol. 16 Issue 1-2 Pg. 11-22 ISSN: 1044-7393 [Print] United States
PMID1520401 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Lactates
  • Organometallic Compounds
  • Pentanones
  • Pyrones
  • aluminum maltolate
  • Lactic Acid
  • tris(acetylacetonate) aluminum(III)
  • Aluminum
Topics
  • Aluminum (chemistry, pharmacology, toxicity)
  • Alzheimer Disease (etiology)
  • Animals
  • Cell Death (drug effects)
  • Cell Division (drug effects)
  • Chemical Phenomena
  • Chemistry, Physical
  • Lactates (pharmacology)
  • Lactic Acid
  • Mice
  • Neuroblastoma (pathology)
  • Organometallic Compounds (pharmacology)
  • Pentanones (pharmacology)
  • Pyrones (pharmacology)
  • Tumor Cells, Cultured (drug effects)

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