Abstract |
Murine neuroblastoma cells behave differently in the presence of Al(acac)3 [acac = 2,4-pentanedionate; acetylacetonate] or Al(malt)3 [malt = 3-hydroxy, 2-methyl, 4-pyronate; maltolate] with respect to Al(lac)3 [lac = 2-hydroxypropionate; lactate]. Thus, a remarkable cytotoxic effect was observed in the first case; on the contrary, an evident cytostatic and neuritogenic effect was produced by aqueous Al(lac)3. The hydrolytically stable complexes Al(acac)3 and Al(malt)3 were both toxic in the concentration range of 0.10-0.30 and 0.10-0.50 mM, respectively, over 24 h. In contrast with this behavior Al(lac)3 displayed a potent cytostatic activity with induction of neurites at 0.2-10 mM. Al( OH)3 manifested biological effects comparable to those exhibited by Al(lac)3. AlPO4 was also cytostatic and led to a morphological differentiation of the neuroblastoma cells, qualitatively different from that elicited by Al(lac)3. The morphological effects induced by Al(lac)3, Al( OH)3, and AlPO4 were irreversible.
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Authors | P Zatta, M Perazzolo, L Facci, S D Skaper, B Corain, M Favarato |
Journal | Molecular and chemical neuropathology
(Mol Chem Neuropathol)
1992 Feb-Apr
Vol. 16
Issue 1-2
Pg. 11-22
ISSN: 1044-7393 [Print] United States |
PMID | 1520401
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Lactates
- Organometallic Compounds
- Pentanones
- Pyrones
- aluminum maltolate
- Lactic Acid
- tris(acetylacetonate) aluminum(III)
- Aluminum
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Topics |
- Aluminum
(chemistry, pharmacology, toxicity)
- Alzheimer Disease
(etiology)
- Animals
- Cell Death
(drug effects)
- Cell Division
(drug effects)
- Chemical Phenomena
- Chemistry, Physical
- Lactates
(pharmacology)
- Lactic Acid
- Mice
- Neuroblastoma
(pathology)
- Organometallic Compounds
(pharmacology)
- Pentanones
(pharmacology)
- Pyrones
(pharmacology)
- Tumor Cells, Cultured
(drug effects)
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