Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice.

Abstract

RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver of Mycobacterium leprae-infected nu/nu mice compared with those of the M. leprae non-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-gamma genes involved in the susceptibility of M. leprae were down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated with M. leprae infection.

• Authors: Byoung Chul Kim, Tae-Jin Kang, Song Hou Jin, Se-Kon Kim, Seong-Boem Lee, Gue-Tae Chae
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 13 Issue 1 Pg. 51-2 (Feb 2004) ISSN: 0962-9351 [Print] United States
• PMID: 15203566 (Publication Type: Journal Article)

Chemical References

• Interleukin-12 Subunit p40
• Protein Subunits
• RNA, Messenger
• Interleukin-12
• Interferon-gamma
• Protein Serine-Threonine Kinases
• Receptor-Interacting Protein Serine-Threonine Kinase 2
• Receptor-Interacting Protein Serine-Threonine Kinases
• Ripk2 protein, mouse

Topics

• Animals
• Down-Regulation
• Female
• Foot
• Interferon-gamma (genetics, metabolism)
• Interleukin-12 (genetics, metabolism)
• Interleukin-12 Subunit p40
• Liver (metabolism)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Mycobacterium Infections (metabolism)
• Mycobacterium leprae
• Protein Serine-Threonine Kinases (genetics, metabolism)
• Protein Subunits (genetics, metabolism)
• RNA, Messenger (metabolism)
• Receptor-Interacting Protein Serine-Threonine Kinase 2
• Receptor-Interacting Protein Serine-Threonine Kinases
• Skin (metabolism)
• Up-Regulation