8-Azidoadenosine and ribonucleotide reductase.

Abstract

Inhibitors of ribonucleotide reductase are potential antiproliferative agents, since they deplete cells from DNA precursors. Substrate nucleoside analogues, carrying azido groups at the base moiety, are shown to have strong cytostatic properties, as measured by the inhibition of the incorporation of thymidine into DNA. One compound, 8-azidoadenosine, inhibits CDP reduction in cytosolic extracts from cancer cells. The corresponding diphosphate behaves as a substrate for ribonucleotide reductase while the triphosphate is an allosteric effector.

• Authors: B Roy, M Lepoivre, J L Decout, J Lhomme, M Fontecave
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 187 Issue 1 Pg. 432-7 (Aug 31 1992) ISSN: 0006-291X [Print] United States
• PMID: 1520331 (Publication Type: Journal Article)

Chemical References

• Azides
• 8-azidoadenosine
• NADP
• 8-azidoadenosine 5'-triphosphate
• Adenosine Diphosphate
• Cytidine Diphosphate
• Adenosine Triphosphate
• Ribonucleotide Reductases
• 8-azidoadenosine diphosphate
• Adenosine

Topics

• Adenosine (analogs & derivatives, pharmacology)
• Adenosine Diphosphate (analogs & derivatives, metabolism)
• Adenosine Triphosphate (analogs & derivatives, pharmacology)
• Allosteric Regulation
• Animals
• Azides (metabolism, pharmacology)
• Cytidine Diphosphate (metabolism)
• Mice
• NADP (metabolism)
• Ribonucleotide Reductases (antagonists & inhibitors)
• Tumor Cells, Cultured