Abstract | BACKGROUND: Pharmacological and neurodevelopmental data support the idea that the gene, which codes for the 5-HT(5A) receptor is an important candidate gene for schizophrenia susceptibility. However, previous genetic studies focusing on this gene yielded conflicting results, potentially because of: (i) stratification biases of case-control association studies, (ii) genetic and phenotypic heterogeneity of schizophrenia, and (iii) variability in the loci analyzed (the 5-HT(5A) gene having many polymorphic sites). METHODS: A transmission disequilibrium test was used in the present study aimed at investigating two polymorphisms in exon 1 of the 5-HT(5A) gene, the A12T silent substitution and the C43T transversion leading to a 15Pro --> Ser substitution, in 103 patients with DSM-IV diagnosis of schizophrenia, and their 206 parents. RESULTS: We found an excess of transmission of the 12T allele from the parents to their affected children (P = 0.02), with evidence for linkage disequilibrium between the 12T-43C haplotype and schizophrenia (P = 0.002). Furthermore, patients with the 12T allele had a significantly later age at onset (P = 0.003), and the Q-TDT approach confirmed that this allele was transmitted with an older age at onset (P = 0.01). CONCLUSIONS: These data provided convergent evidence for a significant role of the 5-HT(5A) gene in schizophrenia and more specifically in patients with later age at onset.
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Authors | C Dubertret, N Hanoun, J Adès, M Hamon, P Gorwood |
Journal | Journal of psychiatric research
(J Psychiatr Res)
2004 Jul-Aug
Vol. 38
Issue 4
Pg. 371-6
ISSN: 0022-3956 [Print] England |
PMID | 15203288
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Serotonin
- serotonin 5 receptor
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Topics |
- Adult
- Age of Onset
- Aged
- Alleles
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Pedigree
- Point Mutation
- Polymorphism, Genetic
- Receptors, Serotonin
(genetics)
- Schizophrenia
(genetics)
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