[Statins in dyslipidemia associated with acute myocardial infarct].

Abstract

Long time ago lipids increased in blood have been known as risk factor for atherosclerosis that causes coronary heart disease among which myocardial infarction is the most complicated. Aim were to present the lipids status structure in patients with acute myocardial infarction and on the basis of that to suggest corresponding statin in treatment. Our research involved 202 patients with acute myocardial infarction, patients were both gender and from 37 to 89 year. Out of total number of patients, 100 of them were with anterior myocardial infarction (group I) and 102 with inferior myocardial infarction (group II). Whole cholesterol, low density lipoproteins, high density lipoproteins and triglycerides were followed. Hi square test and variance analysis were used to prove statistically significant difference. In the sample of group I increased LDL was found in 92 patients and increased TGL in 46 patients while decreased HDL was found in 61 patients. In the sample of group II increased LDL was found in 64 patients, increased TGL in 44 patients, while decreased HDL was found in 51 patients. We analysed the next combinations in both groups: LDL > with HDL <; LDL > with TGL >; HDL < with TGL >; LDL >, TGL > with HDL <. Combination decreased HDL with increased TGL was found in group I in 5 patients, and in group II in 12 patients. Other combinations in both groups were similarly values. On the basis of the obtained results we found statistically significant difference between the two groups of patients. Patients in group I have more frequently increased values of LDL in comparison to patients in group II (p < 0.00005). In patients in group II who had decreased HDL and increased TGL statistically significant difference was found in comparison to the patients in group I (p < 0.02). On the basis of the obtained results and up to now studies on statins effects we suggest Atorvastatin for treatment the patients with anterior myocardial infarction, increased LDL with normal values of HDL and Simvastatin for treatment the patients with inferior myocardial infarction, decreased HDL.

• Authors: Elnur Smajić, Zumreta Kusljugić, Fahir Baraković, Katarina Divković, Nedzada Hukić-Suljkanović, Denis Mrsić, Senada Hujdurović
• Journal: Medicinski arhiv (Med Arh) Vol. 58 Issue 2 Suppl 1 Pg. 21-3 ( 2004) Bosnia and Herzegovina
• Vernacular Title: Statini kod dislipidemije u akutnom infarktu miokarda.
• PMID: 15202301 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Triglycerides
• Cholesterol

Topics

• Adult
• Aged
• Aged, 80 and over
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Female
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hyperlipidemias (blood, complications, drug therapy)
• Male
• Middle Aged
• Myocardial Infarction (blood, complications)
• Triglycerides (blood)