Abstract | PURPOSE OF REVIEW:
Pattern recognition receptors are germ-line encoded receptors that recognize specific pathogen-associated molecules, thereby allowing the innate immune system to distinguish self from nonself structures. Pattern recognition receptors mediate activation of different signaling pathways, resulting in the production of proinflammatory cytokines and the expression of antimicrobial genes. Additionally, pattern recognition receptors play a central role in the activation and direction of the adaptive immune response. This review summarizes recent advances in research trying to elucidate the link between different pattern recognition receptors and inflammatory autoimmune disorders. RECENT FINDINGS: SUMMARY:
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Authors | Reinhart Seibl, Diego Kyburz, Roger P Lauener, Steffen Gay |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 16
Issue 4
Pg. 411-8
(Jul 2004)
ISSN: 1040-8711 [Print] United States |
PMID | 15201605
(Publication Type: Journal Article, Review)
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Chemical References |
- Adaptor Proteins, Signal Transducing
- CARD Signaling Adaptor Proteins
- Carrier Proteins
- Membrane Glycoproteins
- Membrane Proteins
- NOD1 protein, human
- Nod1 Signaling Adaptor Protein
- Receptors, Cell Surface
- Receptors, Immunologic
- TREM1 protein, human
- TYROBP protein, human
- Toll-Like Receptors
- Triggering Receptor Expressed on Myeloid Cells-1
- CARD14 protein, human
- Guanylate Cyclase
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Topics |
- Adaptor Proteins, Signal Transducing
- Arthritis
(immunology)
- CARD Signaling Adaptor Proteins
- Carrier Proteins
(immunology)
- Guanylate Cyclase
(immunology)
- Humans
- Membrane Glycoproteins
(immunology)
- Membrane Proteins
(immunology)
- Nod1 Signaling Adaptor Protein
- Receptors, Cell Surface
(immunology)
- Receptors, Immunologic
(immunology)
- Toll-Like Receptors
- Triggering Receptor Expressed on Myeloid Cells-1
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