Abstract |
A 67-year-old male was admitted because of lymphocytosis and huge splenomegaly. Abnormal lymphocytes had cytoplasmic hairy projections and were negative for tartrate-resistant acid phosphatase staining. The bone marrow aspirate contained many lymphocytes with the same morphology. Flow cytometric analysis revealed an increase in IgM and kappa positive B cells. They were positive for CD11c, CD19, CD20 and FMC7, and negative for CD5, CD10 and CD25. The patient was diagnosed as having hairy cell leukemia, Japanese variant. Initially interferon-alpha was administered for a month, decreasing the numbers of leukemic cells but with little effect on splenomegaly. Subsequent administration of cladribine (0.09 mg/kg, 7 days) showed a remarkable effect, and the patient has been in complete remission for 8 months.
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Authors | Mutsuko Miyazaki, Akihiko Taguchi, Shizu Sakuragi, Noriyuki Mitani, Kazuyuki Matsuda, Kenji Shinohara |
Journal | [Rinsho ketsueki] The Japanese journal of clinical hematology
(Rinsho Ketsueki)
Vol. 45
Issue 5
Pg. 405-7
(May 2004)
ISSN: 0485-1439 [Print] Japan |
PMID | 15199752
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Cladribine
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Topics |
- Aged
- Antineoplastic Agents
(therapeutic use)
- Cladribine
(therapeutic use)
- Humans
- Leukemia, Hairy Cell
(drug therapy)
- Male
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