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[Hairy cell leukemia, Japanese variant, successfully treated with cladribine].

Abstract
A 67-year-old male was admitted because of lymphocytosis and huge splenomegaly. Abnormal lymphocytes had cytoplasmic hairy projections and were negative for tartrate-resistant acid phosphatase staining. The bone marrow aspirate contained many lymphocytes with the same morphology. Flow cytometric analysis revealed an increase in IgM and kappa positive B cells. They were positive for CD11c, CD19, CD20 and FMC7, and negative for CD5, CD10 and CD25. The patient was diagnosed as having hairy cell leukemia, Japanese variant. Initially interferon-alpha was administered for a month, decreasing the numbers of leukemic cells but with little effect on splenomegaly. Subsequent administration of cladribine (0.09 mg/kg, 7 days) showed a remarkable effect, and the patient has been in complete remission for 8 months.
AuthorsMutsuko Miyazaki, Akihiko Taguchi, Shizu Sakuragi, Noriyuki Mitani, Kazuyuki Matsuda, Kenji Shinohara
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 45 Issue 5 Pg. 405-7 (May 2004) ISSN: 0485-1439 [Print] Japan
PMID15199752 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Cladribine
Topics
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Cladribine (therapeutic use)
  • Humans
  • Leukemia, Hairy Cell (drug therapy)
  • Male

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