Abstract | OBJECTIVE: METHODS: Seventy-eight Senile patients with CHD were randomly divided into the TZA group and the PVT group, 39 in each group. Changes of carotid arterial intima-media thickness (IMT) and brachial arterial endothelium dependent diastolic function (FMD) before and after treatment were observed by non-invasive ultrasound test technique, and levels of serum nitric oxide (NO) and plasma endothelin-1 (ET-1) were determined as well. RESULTS: After TAZ treatment, IMT decreased from 1.21 +/- 0.17 mm to 0.91 +/- 0.13 mm, FMD increased from 5.02 +/- 0.58% to 8.97 +/- 0.39%, ET-1 lowered from 95.93 +/- 19.41 ng/L to 49.35 +/- 53.27 ng/L, and NO enhanced from 42.56 +/- 14.12 mumol/L to 69.84 +/- 21.96 mumol/L; after PVT treatment, the corresponding changes were 1.25 +/- 0.21 mm to 0.88 +/- 0.32 mm, 4.90 +/- 0.37% to 8.12 +/- 0.25%, 89.35 +/- 10.02 ng/L to 47.96 +/- 11.05 ng/L and 51.71 +/- 9.39 mumol/L to 72.93 +/- 16.51 mumol/L, all the changes were statistically significant. CONCLUSION: TZA can obviously improve the vascular endothelial function in old patients with CHD, which has the anti- atherosclerosis effect similar to that of PVT.
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Authors | Ben-ling Qi, Bei Cheng, Qiao-hong Zhang |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 24
Issue 5
Pg. 404-7
(May 2004)
ISSN: 1003-5370 [Print] China |
PMID | 15199622
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drugs, Chinese Herbal
- taizhi'an
- Pravastatin
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Topics |
- Aged
- Angina Pectoris
(diagnostic imaging, drug therapy, physiopathology)
- Carotid Arteries
(diagnostic imaging, pathology, physiopathology)
- Coronary Disease
(diagnostic imaging, drug therapy, physiopathology)
- Drug Therapy, Combination
- Drugs, Chinese Herbal
(therapeutic use)
- Endothelium, Vascular
(physiopathology)
- Female
- Humans
- Male
- Phytotherapy
- Pravastatin
(therapeutic use)
- Ultrasonography
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