[Clinical study on treatment of mild cognitive impairment by modified wuzi yanzong granule].

Abstract

OBJECTIVE:

To observe the clinical efficacy and safety of modified Wuzi Yanzong Granule (MWYG) in treating mild cognitive impairment (MCI), and to explore its mechanism.

METHODS:

Forty-four MCI patients were selected referring to the international recognized Peterson's criteria and randomly divided into two groups, the treated group treated with MWYG and the control group treated with Ginkgo leaf extraction, with the course of 3 months for both groups. Changes of memorial quotient (MQ), superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, mitochondrial DNA (mtDNA) deletion rate and acetylcholinesterase (AchE) before and after treatment were observed.

RESULTS:

After treatment, levels of MQ, serum SOD activity increased and serum MDA content, mtDNA deletion rate and AchE decreased in both groups (P < 0.01), but the difference between the two groups was insignificant. No adverse reaction was found in two groups.

CONCLUSION:

Both MWYG and Ginkgo leaf capsule can effectively improve the memorial function of patients with MCI, the therapeutic mechanism is possibly related with the actions in reducing AchE activity, improving free radical metabolism, and alleviating mitochondrial DNA oxidation damage.

• Authors: Xue-mei Wang, Hong Fu, Geng-xin Liu
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 24 Issue 5 Pg. 392-5 (May 2004) ISSN: 1003-5370 [Print] China
• PMID: 15199619 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Mitochondrial
• Drugs, Chinese Herbal
• Malondialdehyde
• Superoxide Dismutase

Topics

• Aged
• Cognition Disorders (blood, drug therapy)
• DNA, Mitochondrial (blood)
• Double-Blind Method
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Ginkgo biloba
• Humans
• Intelligence Tests
• Male
• Malondialdehyde (blood)
• Middle Aged
• Phytotherapy
• Superoxide Dismutase (blood)