Abstract | OBJECTIVE: METHODS: This is a retrospective analysis of all women with OC who were treated in our institution between 1992 and 2000. A total of 98 patients with stages IIIc-IV of OC underwent primary cytoreductive surgery which was 'optimal' (<1 cm residual disease). All patients subsequently received postoperative platinum-containing chemotherapy. Group I, consisting of 51 patients underwent LNX; Group II, consisting of 47 patients did not undergo LNX. The percentage of patients failing to respond to chemotherapy in each group was similar. Each group had statistically equivalent age, stage, regimens of chemotherapy performed, and all other known prognostic factors. RESULTS: No survival benefit could be seen in platinum-sensitive patients. However, in patients who failed to respond to chemotherapy, the 2-year progression-free survival (PFS) (42.8% vs. 14.3%) and overall survival (OS) (51.2% vs. 28.8%) was quite different. LNX significantly improved those of drug-resistant patients when optimal cytoreductive surgery was performed [P = 0.008, risk ratio (rr) = 2.675, 95% confidence interval (CI) = 1.251-5.724]. Cox's proportional analysis shows that LNX was one of the three most significant covariate with the tumor grade and the number of postoperative residual lesions. CONCLUSIONS:
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Authors | Seiji Isonishi, Shigeki Niimi, Hiroshi Sasaki, Kazunori Ochiai, Makoto Yasuda, Tadao Tanaka |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 93
Issue 3
Pg. 647-52
(Jun 2004)
ISSN: 0090-8258 [Print] United States |
PMID | 15196859
(Publication Type: Journal Article)
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Chemical References |
- Irinotecan
- Doxorubicin
- Cyclophosphamide
- Carboplatin
- Paclitaxel
- Cisplatin
- Camptothecin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Carboplatin
(administration & dosage)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Disease-Free Survival
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Irinotecan
- Lymph Node Excision
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Ovarian Neoplasms
(drug therapy, pathology, surgery)
- Paclitaxel
(administration & dosage)
- Retrospective Studies
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