Abstract | BACKGROUND: OBJECTIVE: METHODS: C3H/He mice were sensitized by intratracheal administration of Dermatophagoides farinae (Der f). Mice were orally treated with rosmarinic acid in perilla extract (PE) (1.5 mg/mouse/day). RESULTS: Der f challenge of sensitized mice elicited pulmonary eosinophilic inflammation, accompanied by an increase in lung expression of IL-4 and IL-5, and eotaxin. Daily treatment with rosmarinic acid in PE significantly prevented the increases in the numbers of eosinophils in bronchoalveolar lavage fluids and also in those around murine airways. Rosmarinic acid in PE treatment also inhibited the enhanced protein expression of IL-4 and IL-5, and eotaxin in the lungs of sensitized mice. Der f challenge also enhanced allergen-specific IgG1, which were also inhibited by rosmarinic acid in PE. CONCLUSION:
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Authors | C Sanbongi, H Takano, N Osakabe, N Sasa, M Natsume, R Yanagisawa, K-I Inoue, K Sadakane, T Ichinose, T Yoshikawa |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 34
Issue 6
Pg. 971-7
(Jun 2004)
ISSN: 0954-7894 [Print] England |
PMID | 15196288
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Cinnamates
- Depsides
- Plant Extracts
- rosmarinic acid
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Topics |
- Administration, Oral
- Allergens
- Animals
- Cinnamates
(administration & dosage)
- Depsides
- Hypersensitivity
(drug therapy, immunology)
- Male
- Mice
- Mice, Inbred C3H
- Mites
- Perilla frutescens
- Phytotherapy
- Plant Extracts
(administration & dosage)
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