Intramuscular bipenicillin vs. intravenous penicillin in the treatment of erysipelas in adults: randomized controlled study.

The objective of the study was to evaluate the efficacy of intramuscular penicillin: mixture of benzyl penicillin and procain penicillin (2 MU x 2 times daily) and intravenous benzyl penicillin (4 MU x 6 times daily) in the treatment of hospitalized adult patients with erysipelas. A prospective randomized unicentric trial was conducted. In total, 112 patients entered the study; 57 in the intramuscular group and 55 patients in the intravenous group completed the trial. The failure rate was 14% for intramuscular group and 20% for the intravenous group (P = 0.40). Local complications such as of the leg abscesses were observed in the two groups (intravenous 9.1%, intramuscular 7%; P = 0477). Of the patients treated with intravenous benzyl penicillin, 25.5% presented complications related to the route (venitis). Intramuscular penicillin should be considered an effective and well-tolerated treatment of erysipelas in adult patients.
AuthorsF Zeglaoui, C Dziri, I Mokhtar, N Ezzine, M Kharfi, M Zghal, B Fazaa, M R Kamoun
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 18 Issue 4 Pg. 426-8 (Jul 2004) ISSN: 0926-9959 [Print] Netherlands
PMID15196155 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Penicillin G Procaine
  • Penicillin G
  • Adult
  • Anti-Bacterial Agents (administration & dosage, adverse effects)
  • Drug Administration Schedule
  • Erysipelas (drug therapy)
  • Female
  • Humans
  • Injections, Intramuscular (adverse effects)
  • Injections, Intravenous (adverse effects)
  • Male
  • Penicillin G (administration & dosage, adverse effects)
  • Penicillin G Procaine (administration & dosage, adverse effects)
  • Treatment Failure

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