Novel approaches to ocular drug delivery.

Abstract

Recent advances in surgical techniques, therapeutic approaches and materials sciences have produced revolutionary new therapies for ocular diseases. The development of prodrug formulations and permeability enhancers, sustained-release drug delivery devices, novel injectable medications and new and improved vectors, both viral and non-viral, for delivery of genes to all segments of the eye has greatly increased the chances of success in treating eye diseases. This review will discuss the most recent advances in drug delivery systems for the treatment of ocular diseases.

• Authors: Jennifer L Davis, Brian C Gilger, Michael R Robinson
• Journal: Current opinion in molecular therapeutics (Curr Opin Mol Ther) Vol. 6 Issue 2 Pg. 195-205 (Apr 2004) ISSN: 1464-8431 [Print] England
• PMID: 15195932 (Publication Type: Journal Article)

Chemical References

• Prodrugs
• Cyclosporine

Topics

• Animals
• Cyclosporine (administration & dosage, therapeutic use)
• Drug Administration Routes
• Drug Delivery Systems
• Eye (anatomy & histology)
• Eye Diseases (drug therapy, surgery)
• Genetic Therapy (methods)
• Humans
• Prodrugs (administration & dosage, metabolism)
• Prostheses and Implants