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[Preparation and the anti-tumor activity of mutant Staphylococcal enterotoxin B].

AbstractAIM:
To prepare mutant Staphylococcal enterotoxin B(SEB) and observe its anti-tumor activity.
METHODS:
The expressed mutant SEB-K172E in inclusion body was denatured and renatured, and then isolated and purified. The anti-tumor activity of the mutant SEB-K172E was compared with wild-type SEB.
RESULTS:
Renaturation and purification method of the mutant SEB-K172E was developed. The anti-tumor activity of acquired mutant protein was ten times higher than that of wild-type SEB.
CONCLUSION:
The anti-tumor activity of the mutant SEB-K172E is much higher than that of wild-type SEB, suggesting that the mutant SEB-K172E may become a potential anti-tumor drug.
AuthorsXiao-hong Deng, Yu-ling Zheng, Feng Yu, Bao-an Ning, Yong-qiang Jiang
JournalXi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) Vol. 20 Issue 3 Pg. 360-2 (May 2004) ISSN: 1007-8738 [Print] China
PMID15193239 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Enterotoxins
  • Superantigens
  • enterotoxin B, staphylococcal
Topics
  • Antineoplastic Agents (pharmacology)
  • Enterotoxins (biosynthesis, genetics, pharmacology)
  • HT29 Cells (drug effects)
  • Humans
  • Point Mutation
  • Protein Renaturation
  • Staphylococcus aureus (genetics)
  • Superantigens (biosynthesis, genetics, pharmacology)

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