Abstract | BACKGROUND: The plasminogen activator (PA) system plays many roles in the inflammatory process and tissue remodelling and repair and is considered to play a significant role in periodontal tissue destruction and healing. The aim of this study was to evaluate the role of the PA system in cyclosporin A (CsA)-induced gingival overgrowth in renal transplant patients. METHODS: RESULTS: In CsA GO+ sites t-PA levels were significantly elevated in comparison with gingivitis and healthy sites, while PAI-2 levels in these sites showed statistically significant differences only with CsA-H and gingivitis sites (p<0.05). The levels of t-PA and PAI-2 were significantly higher in CsA GO- sites compared with those of CsA-H, gingivitis and healthy sites (p<0.05). The levels of u-PA and PAI-1 failed to show significant differences between the study groups. CONCLUSIONS: The findings of the present study indicate alterations in GCF t-PA and PAI-2 levels in CsA-induced gingival overgrowth and might suggest involvement of the plasminogen activating system in the pathogenesis of this side-effect of CsA therapy. However, to what extent these molecules contribute to the pathogenesis of CsA-induced gingival overgrowth remains to be determined.
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Authors | Nurcan Buduneli, Eralp Buduneli, Sema Ciotanar, Gül Atilla, David Lappin, Denis Kinane |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 31
Issue 7
Pg. 556-61
(Jul 2004)
ISSN: 0303-6979 [Print] United States |
PMID | 15191592
(Publication Type: Journal Article)
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Chemical References |
- Plasminogen Inactivators
- Cyclosporine
- Tissue Plasminogen Activator
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Topics |
- Adult
- Analysis of Variance
- Case-Control Studies
- Cyclosporine
(adverse effects)
- Enzyme-Linked Immunosorbent Assay
- Female
- Gingival Crevicular Fluid
(chemistry, metabolism)
- Gingival Overgrowth
(chemically induced, metabolism)
- Humans
- Kidney Transplantation
- Male
- Plasminogen Inactivators
(analysis, metabolism)
- Statistics, Nonparametric
- Tissue Plasminogen Activator
(analysis, metabolism)
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