Predictive value of SCC-Ag, CYFRA 21-1 and selected acute phase proteins in radiotherapy of pharyngeal and laryngeal cancer. A preliminary report.

Abstract

The diagnostic sensitivity and specificity of tumor markers in head and neck cancers is not satisfactory. It is a stimulus for search of other biochemical indicators, among others determinations of acute phase proteins, helpful in head and neck cancers diagnostics and prognosis. In a group of 33 patients with squamous cell carcinoma of the pharynx and larynx (T1-4 N0-3 M0) CYFRA 21-1, SCC-Ag and acute phase proteins such as prealbumin, albumin, alpha-1 acid glycoprotein, alpha-1 antytrypsin, transferrin, ceruloplasmin and C-reactive protein (CRP) determinations were performed before radiotherapy. Significantly greater area under ROC curve for CYFRA 21-1 than for SCC-Ag was found. In T3-4 group, significantly lower albumin and higher AAG and CRP concentrations in comparison with T1-2 patients were observed. Multivariate analysis revealed that apart from tumor stage, elevated concentrations of SCC-Ag and/or CRP are independent unfavorable prognostic factors.

• Authors: J Kulpa, Z Stasik, J Skołyszewski, E Wójcik, U Rychlik, K Pudełek
• Journal: Neoplasma (Neoplasma) Vol. 51 Issue 2 Pg. 103-9 ( 2004) ISSN: 0028-2685 [Print] Slovakia
• PMID: 15190419 (Publication Type: Journal Article)

Chemical References

• Acute-Phase Proteins
• Antigens, Neoplasm
• Biomarkers, Tumor
• Keratin-19
• Serpins
• antigen CYFRA21.1
• squamous cell carcinoma-related antigen
• Keratins

Topics

• Acute-Phase Proteins (biosynthesis)
• Antigens, Neoplasm (biosynthesis)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, radiotherapy)
• Humans
• Keratin-19
• Keratins
• Laryngeal Neoplasms (metabolism, mortality, radiotherapy)
• Multivariate Analysis
• Pharyngeal Neoplasms (metabolism, mortality, radiotherapy)
• Prognosis
• ROC Curve
• Sensitivity and Specificity
• Serpins (biosynthesis)
• Time Factors
• Treatment Outcome