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Effectiveness of therapy with iloprost in hand-arm vibration syndrome.

AbstractAIM:
To evaluate the efficacy and tolerance of therapy with iloprost in hand-arm vibration syndrome.
METHODS:
We describe a clinical case of a male aged 53 years, who was a heavy smoker for 30 years and a mason working with vibrating tools since 1962. He presented with a history of 10 years of attacks of vasospasm, functional impairment and digital ulceration. He was diagnosed as having hand-arm vibration syndrome vascular stage 4 on the Stockholm Workshop 1986 Scale. Besides suspension from work and abstention from smoking, we began intravenous infusion of iloprost for 6 h in cycles of 3-6 consecutive days, arriving at a dose of 1.5-2.0 ng/kg/min.
RESULTS:
After eight cycles, he reported significant symptomatic and functional improvement. Iloprost was seen to be efficacious: the trophic skin lesions disappeared and his microcirculatory perfusion tests improved. There were no significant side effects.
CONCLUSIONS:
We suggest that the use of iloprost in the treatment of the most advanced stages of vascular hand-arm vibration syndrome warrants further study
AuthorsMichele Meloni, Mario Torrazza, Roberto Ledda
JournalOccupational medicine (Oxford, England) (Occup Med (Lond)) Vol. 54 Issue 4 Pg. 261-4 (Jun 2004) ISSN: 0962-7480 [Print] England
PMID15190165 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Vasodilator Agents
  • Iloprost
Topics
  • Arm (blood supply)
  • Arm Injuries (drug therapy, physiopathology)
  • Hand (blood supply)
  • Hand Injuries (drug therapy, physiopathology)
  • Humans
  • Iloprost (administration & dosage)
  • Infusions, Intravenous
  • Male
  • Microcirculation
  • Middle Aged
  • Occupational Diseases (drug therapy, physiopathology)
  • Treatment Outcome
  • Vasodilator Agents (administration & dosage)
  • Vibration (adverse effects)

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