Abstract | STUDY OBJECTIVE: PATIENTS AND METHODS: Twenty-two patients with sepsis (14 patients with severe sepsis and 8 patients with sepsis), and 6 healthy volunteers were evaluated. Sequential analysis of the serum levels of TNF-alpha, TNFRI, FasL, and Fas were performed in these patients using enzyme-linked immunosorbent assays. RESULTS: Detectable levels of TNF-alpha were found in only 8 of 14 patients with severe sepsis. Patients with severe sepsis and sepsis had similarly increased levels of FasL, compared with healthy individuals (p < 0.05). Higher levels of TNFRI and Fas were found in patients with severe sepsis than in patients with sepsis and healthy volunteers (p < 0.001 and p < 0.01, respectively). Fas levels were also higher in patients who died than in those who survived (p < 0.01). A direct relationship was found between serum levels of TNFRI and Fas, and multiorgan dysfunction (sequential organ failure assessment score) [p < 0.0001]. CONCLUSIONS: These results suggest that the TNF-alpha/TNFRI and FasL/Fas systems may be involved in the pathogenesis of sepsis. Serum levels of the death-receptors, TNFRI and Fas, could serve as potential markers of the severity of human sepsis.
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Authors | Ivel De Freitas, Máximo Fernández-Somoza, Eva Essenfeld-Sekler, José E Cardier |
Journal | Chest
(Chest)
Vol. 125
Issue 6
Pg. 2238-46
(Jun 2004)
ISSN: 0012-3692 [Print] United States |
PMID | 15189947
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- fas Receptor
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Topics |
- Adult
- Aged
- Apoptosis
(physiology)
- Biomarkers
(blood)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Probability
- Prognosis
- Receptors, Tumor Necrosis Factor
(analysis)
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Statistics, Nonparametric
- Survival Analysis
- Systemic Inflammatory Response Syndrome
(diagnosis, mortality)
- Tumor Necrosis Factor-alpha
(analysis)
- fas Receptor
(analysis)
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