[Correlation of clinical manifestations of atopic dermatitis in children and the activity of NAD(PH)-dependent dehydrogenases in blood lymphocytes].

Abstract

The bioluminescence was used to study the activity levels of NAD (P)-dependent dehydrogenases in blood lymphocytes of 88 children with atopic dermatitis. The nature and intensity of the investigated enzymes were found to be dependent on age and a disease severity with changes being most pronounced and resistant in the elder age group and in patients with a continuously relapsing disease course. Besides, it was shown that the changes of NAD (P)-dependent dehydrogenases in blood lymphocytes are objectively related with an allergic inflammation clinical course in patients with atopic dermatitis and could be clinically valuable in monitoring the dermatitis progression at the metabolic level, in prognosticating possible relapses and in evaluating a chosen therapy.

• Authors: L M Kurtasova, N A Shakina, A A Savchenko, A R Shmidt
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 4 Pg. 15-8 (Apr 2004) ISSN: 0869-2084 [Print] Russia (Federation)
• Vernacular Title: Vzaimosviaz' klinicheskikh proiavleniĭ atopicheskogo dermatita u deteĭ s aktivnost'iu NAD(F)-zavisimykh degidrogenaz limfotsitov krovi.
• PMID: 15188737 (Publication Type: English Abstract, Journal Article)

Chemical References

• NADPH Dehydrogenase

Topics

• Age Factors
• Child
• Child, Preschool
• Dermatitis, Atopic (blood, diagnosis, enzymology)
• Female
• Humans
• Infant
• Lymphocytes (enzymology)
• Male
• NADPH Dehydrogenase (blood)