Abstract | OBJECTIVE: METHOD: Sixty-nine adolescents (aged 13-19) with conduct disorder (CD), SUD, and ADHD were recruited from the community and randomly assigned to a 12-week clinical trial of pemoline (n = 35) or placebo (n = 34), titrated over 4 weeks to a single morning dose of 75 to 112.5 mg as tolerated. RESULTS:
Pemoline had greater efficacy than placebo for ADHD as determined by significantly more Clinician's Global Impression-Improvement (CGI-I) ratings of 1 (very much improved) or 2 (much improved) at the study endpoint (n = 69; p <.05). There was also greater reduction in ADHD severity on the parent-rated Conners Hyperactivity-Impulsivity scale in pemoline-treated study completers compared to placebo-treated completers ( pemoline, n = 17; placebo, n = 16; p <.01), but no difference between groups in the intent-to-treat analysis (n = 68; p <.13). Substance use did not decline in either group, and there was no difference between groups in baseline to study endpoint change in substance use or CD symptoms. Overall, pemoline was well tolerated, demonstrating a good safety profile and no elevation in liver enzyme levels. CONCLUSIONS:
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Authors | Paula D Riggs, Shannon K Hall, Susan K Mikulich-Gilbertson, Michelle Lohman, Ashley Kayser |
Journal | Journal of the American Academy of Child and Adolescent Psychiatry
(J Am Acad Child Adolesc Psychiatry)
Vol. 43
Issue 4
Pg. 420-9
(Apr 2004)
ISSN: 0890-8567 [Print] United States |
PMID | 15187802
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Central Nervous System Stimulants
- Pemoline
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Topics |
- Adolescent
- Adult
- Attention Deficit Disorder with Hyperactivity
(drug therapy)
- Central Nervous System Stimulants
(therapeutic use)
- Conduct Disorder
(drug therapy)
- Diagnosis, Dual (Psychiatry)
- Female
- Humans
- Male
- Pemoline
(therapeutic use)
- Safety
- Statistics, Nonparametric
- Substance-Related Disorders
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