Analgesic, antiinflammatory and central depressor effects of the hydroalcoholic extract and fractions from Aeolanthus suaveolens.

Abstract

This work studied antinociceptive, antiedematogenic and central depressor effects of the hydroalcoholic extract (HAE) from Aeolanthus suaveolens and its fractions: hexane (ASHAE-H), ethyl acetate (ASHAE-A), aqueous (ASHAE-E) and precipitate (ASHAE-PPT) in experimental models in mice. The highest activity in the writhing test was presented by ASHAE-A followed by ASHAE-PPT and ASHAE-E and the lowest by ASHAE-H. In the formalin test the effect was manifested at both phases, although more intensely at the 2nd phase of the response. In this test, the most active fraction was ASHAE-PPT causing inhibitions of the order of 76 and 90% of the 2nd phase of the test at the doses of 10 and 100 mg/kg i.p., respectively. Naloxone reversed the effects of ASHAE-PPT in both phases of the test, suggesting the participation of the opioid system in the antinociceptive effect. On the other hand, the HAE effect on both phases of the formalin test was only partially reversed by naloxone, suggesting that the extract presents more than one active compound, and at least one, of a polar nature, acting through the opioid system. HAE and ASHAE-PPT presented antiinflammatory activity and were very effective in decreasing the mouse paw edema induced by carrageenan. All fractions significantly decreased locomotor activity in the open field test in mice. However, only the nonpolar fractions presented myorelaxant activity as demonstrated by the rota rod test.

• Authors: Letícia Veras Costa-Lotufo, David Freitas de Lucena, Manoel Andrade-Neto, José Norberto Sousa Bezerra, Luzia Kalyne Almeida Moreira Leal, Francisca Cléa Florência de Sousa, Glauce Socorro de Barros Viana
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 27 Issue 6 Pg. 821-4 (Jun 2004) ISSN: 0918-6158 [Print] Japan
• PMID: 15187426 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Central Nervous System Depressants
• Plant Extracts
• Ethanol

Topics

• Analgesics (isolation & purification, pharmacology, therapeutic use)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology, therapeutic use)
• Central Nervous System Depressants (isolation & purification, pharmacology, therapeutic use)
• Edema (drug therapy)
• Ethanol (pharmacology, therapeutic use)
• Female
• Lamiaceae
• Male
• Mice
• Pain Measurement (drug effects, methods)
• Plant Extracts (isolation & purification, pharmacology, therapeutic use)
• Plant Leaves