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Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function.

AbstractPURPOSE:
To determine whether ArginMax (The Daily Wellness Co., Sunnyvale, CA) or the Panax ginseng extract it contains has any estrogenic activity. ArginMax for Women, a nutritional supplement for optimization of sexual health, contains L-arginine, ginseng, ginkgo, damiana, multivitamins, and minerals.
METHODS:
A human endometrial adenocarcinoma cell line, Ishikawa, which contains an alkaline phosphatase (AP) enzyme sensitive to estrogen stimulation, was used in a bioassay to determine whether Panax ginseng or ArginMax contained estrogenic components.
RESULTS:
Neither ArginMax nor Panax ginseng stimulated AP at any of the concentrations tested.
CONCLUSIONS:
No estrogenic activity was evident in the sample of Panax ginseng extract tested or in a sample of ArginMax containing this extract in combination with other ingredients.
AuthorsMary Lake Polan, Richard B Hochberg, Aileen S Trant, Hank C K Wuh
JournalJournal of women's health (2002) (J Womens Health (Larchmt)) Vol. 13 Issue 4 Pg. 427-30 (May 2004) ISSN: 1540-9996 [Print] United States
PMID15186659 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • ArginMax
  • Estrogens
  • Glycosides
  • Minerals
  • Plant Extracts
  • Plant Preparations
  • Vitamins
  • Alkaline Phosphatase
Topics
  • Adenocarcinoma (chemistry)
  • Alkaline Phosphatase (drug effects)
  • Biological Assay (methods)
  • Cell Line, Tumor
  • Endometrial Neoplasms (chemistry)
  • Estrogens (analysis)
  • Female
  • Glycosides (chemistry)
  • Humans
  • Menopause
  • Minerals (chemistry)
  • Panax (chemistry)
  • Plant Extracts (chemistry)
  • Plant Preparations
  • Time Factors
  • Vitamins (chemistry)

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