Abstract |
Two brothers from a Chinese family with beta-thalassemia intermedia who harbor both alpha- and beta-globin gene defects are described. They are both compound heterozygous for codons 41/42 (-CTTT) beta0-thalassemia and nt - 28 (A > G) beta(+)-thalassemia mutations together with concurrent (- -SEA) alpha-thalassemia (SEA) deletion. One sibling also harbors Hb Westmead, giving an unusual genotype of beta0/ beta(+)-thalassemia and (- -SEA) alpha-thalassemia/ Hb Westmead. With respect to the age at presentation and transfusion requirement, this subject shows a milder clinical phenotype than his brother, most probably explainable by the presence of Hb Westmead in addition to the SEA deletion, which causes a further amelioration of the alpha-chain excess and hence a less severe disease. For areas with high prevalence of both alpha- and beta-thalassemia mutations, their interactions should always be considered in genotype phenotype correlation. Moreover, routine laboratory diagnostic strategy for non-deletional alpha-globin gene mutations in the Chinese may need to include Hb Westmead, as it is a common alpha-globin gene mutation in our population apart from Hb Constant Spring and Hb Quong Sze.
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Authors | Wai-Shan Wong, Amy Y Y Chan, Sze-Fai Yip, Edmond Shiu-Kwan Ma |
Journal | Hemoglobin
(Hemoglobin)
Vol. 28
Issue 2
Pg. 151-6
(May 2004)
ISSN: 0363-0269 [Print] England |
PMID | 15182058
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Codon
- Hemoglobins, Abnormal
- Glutamine
- hemoglobin Quong Sze
- Histidine
- Hemoglobin Westmead
- Globins
- Hemoglobin Constant Spring
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Topics |
- Adult
- Asian People
- China
- Codon
(genetics)
- DNA Mutational Analysis
- Family
- Genotype
- Globins
(genetics, metabolism)
- Glutamine
(genetics)
- Hemoglobins, Abnormal
(genetics, metabolism)
- Histidine
(genetics)
- Humans
- Inclusion Bodies
(metabolism)
- Male
- Phenotype
- Sequence Deletion
(genetics)
- alpha-Thalassemia
(genetics)
- beta-Thalassemia
(genetics, metabolism)
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