HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of anaemia in inflammatory bowel disease with iron sucrose.

AbstractBACKGROUND:
Inflammatory bowel disease (IBD)-associated anaemia usually responds to intravenous iron. If not, additive treatment with erythropoietin has been proposed. The objective of the present retrospective study was to evaluate the effectiveness of treatment with iron sucrose alone.
METHODS:
Sixty-one patients with IBD and anaemia (average haemoglobin 97 g/L) were treated with iron sucrose (iron dose 1.4 +/- 0.5 g). The indications for iron sucrose were poor response and/or intolerance to oral iron. Treatment response was defined as an increase in haemoglobin of > or = 20 g/L or to normal haemoglobin levels (> or = 120 g/L). Two independent investigators retrospectively assessed laboratory variables, clinical findings, and concomitant medication.
RESULTS:
Two patients were transferred to other hospitals after treatment and therefore could not be evaluated. Fifty-four of the remaining 59 patients (91%) responded within 12 weeks. Sixty percent of the patients had responded within 8 weeks. Five patients had no or only a partial response to iron sucrose of which three had prolonged gastrointestinal blood losses. Eight patients with normal or elevated levels of ferritin could be considered to have anaemia of chronic disease, and all of them responded to iron sucrose. During a follow-up period of 117 +/- 85 (4-291) (mean +/- s (standard deviation) (range)) weeks 19 patients (32%) needed at least one second course of iron sucrose because of recurrent disease.
CONCLUSIONS:
Anaemia associated with IBD can be successfully treated with intravenously administered iron sucrose, provided that bowel inflammation is treated adequately and enough iron is given. Treatment with iron sucrose is safe. Follow-up of haemoglobin and iron parameters to avoid further iron deficiency anaemia is recommended.
AuthorsG Bodemar, S Kechagias, S Almer, B G Danielson
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 39 Issue 5 Pg. 454-8 (May 2004) ISSN: 0036-5521 [Print] England
PMID15180183 (Publication Type: Journal Article)
Chemical References
  • Ferric Compounds
  • Hematinics
  • Sucrose
  • Ferric Oxide, Saccharated
  • Glucaric Acid
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia (diagnosis, drug therapy, etiology)
  • Colitis, Ulcerative (complications)
  • Crohn Disease (complications)
  • Female
  • Ferric Compounds (administration & dosage, adverse effects, therapeutic use)
  • Ferric Oxide, Saccharated
  • Glucaric Acid
  • Hematinics (administration & dosage, adverse effects, therapeutic use)
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Retreatment
  • Retrospective Studies
  • Sucrose (administration & dosage, adverse effects, therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: