[Activity of the messenger systems in the altitude chamber hypoxia].

Abstract

The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) caused further impairments in the second messenger content. The synergism between phosphoinositide and adenylatcyclase systems was demonstrated.

• Authors: A A Vishnevskiĭ, V M Iakovlev, Z I Khabibullova
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2004 Mar-Apr Vol. 50 Issue 2 Pg. 187-91 ISSN: 2310-6972 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' messendzhernykh sistem pri barokamernoĭ gipoksii.
• PMID: 15179826 (Publication Type: Journal Article)

Chemical References

• Adenylyl Cyclase Inhibitors
• Adrenergic beta-Antagonists
• Phosphatidylinositols
• Lithium
• Propranolol
• Adenylyl Cyclases

Topics

• Adenylyl Cyclase Inhibitors
• Adenylyl Cyclases (metabolism)
• Adrenergic beta-Antagonists (pharmacology)
• Altitude
• Animals
• Brain (enzymology, metabolism)
• Hypoxia (enzymology, metabolism)
• Lithium (pharmacology)
• Phosphatidylinositols (antagonists & inhibitors, metabolism)
• Propranolol (pharmacology)
• Rats
• Second Messenger Systems (physiology)