Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.

Abstract

A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.

• Authors: Akitsu Ogawa, Chikako Murakami, Shinji Kamisuki, Isoko Kuriyama, Hiromi Yoshida, Fumio Sugawara, Yoshiyuki Mizushina
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 13 Pg. 3539-43 (Jul 05 2004) ISSN: 0960-894X [Print] England
• PMID: 15177469 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Chromans
• pseudodeflectusin
• Glutathione

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Aspergillus (chemistry)
• Chromans (chemistry, isolation & purification, pharmacology)
• Eukaryota (microbiology)
• Female
• Glutathione (metabolism)
• HL-60 Cells
• HeLa Cells
• Humans
• Male
• Molecular Structure
• Tumor Cells, Cultured