Abstract | UNLABELLED: INTRODUCTION: High serum cytokines levels are not always associated with hypercalcemia in patients with adult T-cell leukemia (ATL), suggesting that other factors are involved in the pathogenesis of ATL patients with hypercalcemia. This study was designed to determine the role of macrophage inflammatory protein-1alpha (MIP-1alpha), a chemokine recently described as an osteoclast stimulatory factor, in ATL-associated hypercalcemia. MATERIALS AND METHODS: RESULTS: CONCLUSION: Our results suggest that MIP-1alpha can induce RANKL on ATL cells in autocrine fashion and that RANKL seems to mediate the hypercalcemic effect of MIP-1alpha in ATL. We propose that MIP-1alpha is the clinical hallmark of hypercalcemia in ATL and could be a potentially useful therapeutic target.
|
Authors | Yosuke Okada, Junichi Tsukada, Kazuhisa Nakano, Shinichi Tonai, Shinichiro Mine, Yoshiya Tanaka |
Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
(J Bone Miner Res)
Vol. 19
Issue 7
Pg. 1105-11
(Jul 2004)
ISSN: 0884-0431 [Print] United States |
PMID | 15176993
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carrier Proteins
- Chemokine CCL3
- Chemokine CCL4
- Cytokines
- Macrophage Inflammatory Proteins
- Membrane Glycoproteins
- Parathyroid Hormone-Related Protein
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
- TNFRSF11A protein, human
- TNFSF11 protein, human
|
Topics |
- Carrier Proteins
(blood, metabolism)
- Cell Movement
(physiology)
- Chemokine CCL3
- Chemokine CCL4
- Cytokines
(blood, metabolism)
- Female
- Humans
- Hypercalcemia
(etiology, immunology, metabolism)
- Leukemia-Lymphoma, Adult T-Cell
(complications, diagnosis, metabolism)
- Macrophage Inflammatory Proteins
(blood, physiology)
- Male
- Membrane Glycoproteins
(blood, metabolism)
- Monocytes
(physiology)
- Osteoblasts
(metabolism)
- Parathyroid Hormone-Related Protein
(blood)
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
- T-Lymphocytes
(metabolism)
|