Prevention of bone loss by oil extract of garlic (Allium sativum Linn.) in an ovariectomized rat model of osteoporosis.

Abstract	The effects of oil extract of garlic (Allium sativum Linn.) on different primary and secondary osteoporotic marker changes were tested in an ovariectomized rat model of osteoporosis. Experiments were performed on three different rat models: sham-operated control, ovariectomized and ovariectomized supplemented with garlic oil. In ovariectomized group, there has been a significant increase in different relative organ weights compared to sham-operated control, while the uterine weight was found to be decreased. Supplementation with oil extract of garlic could effectively reverse these changes. Also low bone densities that developed in the ovariectomized group were significantly recovered in the garlic oil supplemented group. In our study, the development of high rate of bone turnover and osteoporosis in the ovariectomized animals were confirmed by significant alteration of serum alkaline phosphatase activity, serum tartrate resistant acid phosphatase activity, urinary excretion of calcium, phosphate, hydroxyproline and urinary calcium to creatinine ratio, when compared with the sham-operated control group. Garlic oil extract supplementation, apart from its unique influence in lowering blood cholesterol, could also prevent ovariectomy-induced rise in all the above-mentioned marker changes. The results of this study emphasize that oil extract of garlic possibly has a positive role in suppressing ovariectomy-induced bone resorption.
Authors	M Mukherjee, A S Das, S Mitra, C Mitra
Journal	Phytotherapy research : PTR (Phytother Res) Vol. 18 Issue 5 Pg. 389-94 (May 2004) ISSN: 0951-418X [Print] England
PMID	15173999 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 2004 John Wiley & Sons, Ltd.
Chemical References	Plant Oils Alkaline Phosphatase
Topics	Alkaline Phosphatase (blood) Animals Bone Density (drug effects) Disease Models, Animal Female Garlic Organ Size (drug effects) Osteoporosis (blood, prevention & control, urine) Ovariectomy Phytotherapy Plant Oils (administration & dosage, pharmacology, therapeutic use) Rats

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