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Effects of esculentoside A on production of interleukin-1, 2, and prostaglandin E2.

AbstractAIM:
To investigate the influence of esculentoside A (EsA) on immunological function and its mechanism of anti-inflammation.
METHODS:
Interleukin-1 production was measured by thymocyte co-stimulating assay; the radioactivity of [(3)H]arachidonic acid (AA) was used to evaluate the release of AA; prostaglandin E2 production was measured with radioimmunoassay (RIA); IL-2 and IFN-gamma were detected by ELISA method.
RESULTS:
EsA (3-12 micromol/L)could potently inhibit the production of IL-1 and PGE(2) from both silent and LPS induced macrophages. EsA had no significant effect on the release of AA from murine macrophages. EsA could inhibit the production of IL-2 from murine lymphocytes induced by ConA, but not affect the production from silent lymphocytes. EsA showed no effect on the production of IFN-gamma from both silent and ConA induced lymphocytes.
CONCLUSION:
EsA could affect the immunological function through inhibiting the production of IL-2 from activated splenocytes and the inhibition of production of IL-1 and PGE(2) might be one of the anti-inflammation mechanisms of EsA.
AuthorsZhen-Yu Xiao, Qin-Yue Zheng, Yuan-Ying Jiang, Bin Zhou, Ming Yin, Hong-Bin Wang, Jun-Ping Zhang
JournalActa pharmacologica Sinica (Acta Pharmacol Sin) Vol. 25 Issue 6 Pg. 817-21 (Jun 2004) ISSN: 1671-4083 [Print] United States
PMID15169638 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Interleukin-1
  • Interleukin-2
  • Saponins
  • Arachidonic Acid
  • esculentoside A
  • Oleanolic Acid
  • Interferon-gamma
  • Dinoprostone
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Arachidonic Acid (metabolism)
  • Dinoprostone (biosynthesis)
  • Drugs, Chinese Herbal (pharmacology)
  • Female
  • Interferon-gamma (biosynthesis)
  • Interleukin-1 (biosynthesis)
  • Interleukin-2 (biosynthesis)
  • Lymphocytes (metabolism)
  • Macrophages, Peritoneal (metabolism)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Oleanolic Acid (analogs & derivatives, isolation & purification, pharmacology)
  • Phytolacca (chemistry)
  • Plants, Medicinal (chemistry)
  • Saponins (isolation & purification, pharmacology)

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