HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Relationship between the changes in placental blood flow resistance assessed by Doppler technique and maternal serum placental aminopeptidases, which degrade vaso-active peptides, in pre-eclampsia.

Abstract
Our study showed that there were statistically significant correlations between the systolic and diastolic ratio (S/D) of maternal uterine or umbilical artery and the levels of maternal serum aminopeptidase activities in pre-eclampsia. Kininase I was positively correlated with the S/D ratios, whereas placental leucine aminopeptidase (P-LAP) and aminopeptidase A were negatively correlated with the S/D ratios. It is known that the increased S/D ratios reflect the increased utero-placental blood flow resistance. Since our previous study showed that placental aminopeptidases degrade vasoactive peptides such as oxytocin, angiotensin and bradykinin, which the fetus actively produces, our present study suggests that the increased vascular resistance in feto-placental circulation in pre-eclampsia is partly controlled by changes in vaso-active peptides, via degradation by placental aminopeptidases.
AuthorsY Asada, S Mizutani, M Kasugai, O Kurauchi, Y Tomoda
JournalHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 24 Issue 7 Pg. 342-4 (Jul 1992) ISSN: 0018-5043 [Print] Germany
PMID1516891 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptides
  • Aminopeptidases
  • Glutamyl Aminopeptidase
  • Lysine Carboxypeptidase
Topics
  • Adult
  • Aminopeptidases (blood)
  • Female
  • Glutamyl Aminopeptidase
  • Humans
  • Lysine Carboxypeptidase (blood)
  • Peptides (metabolism)
  • Placenta (blood supply, diagnostic imaging, enzymology)
  • Pre-Eclampsia (enzymology)
  • Pregnancy
  • Regional Blood Flow (physiology)
  • Ultrasonography
  • Uterus (blood supply)
  • Vascular Resistance

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: