Abstract |
Our study showed that there were statistically significant correlations between the systolic and diastolic ratio (S/D) of maternal uterine or umbilical artery and the levels of maternal serum aminopeptidase activities in pre-eclampsia. Kininase I was positively correlated with the S/D ratios, whereas placental leucine aminopeptidase (P-LAP) and aminopeptidase A were negatively correlated with the S/D ratios. It is known that the increased S/D ratios reflect the increased utero-placental blood flow resistance. Since our previous study showed that placental aminopeptidases degrade vasoactive peptides such as oxytocin, angiotensin and bradykinin, which the fetus actively produces, our present study suggests that the increased vascular resistance in feto-placental circulation in pre-eclampsia is partly controlled by changes in vaso-active peptides, via degradation by placental aminopeptidases.
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Authors | Y Asada, S Mizutani, M Kasugai, O Kurauchi, Y Tomoda |
Journal | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
(Horm Metab Res)
Vol. 24
Issue 7
Pg. 342-4
(Jul 1992)
ISSN: 0018-5043 [Print] Germany |
PMID | 1516891
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptides
- Aminopeptidases
- Glutamyl Aminopeptidase
- Lysine Carboxypeptidase
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Topics |
- Adult
- Aminopeptidases
(blood)
- Female
- Glutamyl Aminopeptidase
- Humans
- Lysine Carboxypeptidase
(blood)
- Peptides
(metabolism)
- Placenta
(blood supply, diagnostic imaging, enzymology)
- Pre-Eclampsia
(enzymology)
- Pregnancy
- Regional Blood Flow
(physiology)
- Ultrasonography
- Uterus
(blood supply)
- Vascular Resistance
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