Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). II. Multireplicated dose-response studies with technical and analytical grades of 2,4,5-T in four-way outcross mice.

Abstract

A series of multireplicated developmental toxicity studies were conducted in four-way outcross mice and CD-1 outbred mice administered either analytical or technical grades of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) by gavage on Gestational Days 6 through 14. The formulations of 2,4,5-T differed by a factor of 10-fold in 2,3,7,8-tetrachlorodibenzo-p-dioxin levels. Reduced fetal weight and increased incidences of cleft palate and embryolethality were the most significant prenatal effects of both formulations of 2,4,5-T observed in all strains/stocks of mice. Both the outcross and outbred mice exhibited a dose-response relationship with each of the above endpoints and the dose-response curves were parallel. There were no embryotoxic or fetotoxic differences between the technical and analytical grades of 2,4,5-T with regard to extent of fetal weight reduction, resorption rate, or cleft palate incidence. There was little difference in the results between the four-way outcross mouse and the CD-1 outbred mouse.

• Authors: C J Nelson, J F Holson, T B Gaines, J B LaBorde, W F McCallum, G L Wolff, D M Sheehan, J F Young
• Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 19 Issue 2 Pg. 298-306 (Aug 1992) ISSN: 0272-0590 [Print] United States
• PMID: 1516788 (Publication Type: Journal Article)

Chemical References

• Teratogens
• 2,4,5-Trichlorophenoxyacetic Acid

Topics

• 2,4,5-Trichlorophenoxyacetic Acid (toxicity)
• Animals
• Body Weight (drug effects)
• Dose-Response Relationship, Drug
• Female
• Hysterectomy
• Mice
• Pregnancy
• Species Specificity
• Teratogens (toxicity)