Abstract | PURPOSE OF REVIEW: The progress in headache genetics, especially migraine genetics, recently jumped ahead with some major discoveries. RECENT FINDINGS: SUMMARY: The findings in familial hemiplegic migraine confirm that dysfunction in ion transport is a key factor in migraine pathophysiology and might help us in the elucidation of migraine molecular pathways. The identification of several migraine susceptibility loci underline its genetically complex nature.
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Authors | Esther E Kors, Kaate R J Vanmolkot, Joost Haan, Rune R Frants, Arn M J M van den Maagdenberg, Michel D Ferrari |
Journal | Current opinion in neurology
(Curr Opin Neurol)
Vol. 17
Issue 3
Pg. 283-8
(Jun 2004)
ISSN: 1350-7540 [Print] England |
PMID | 15167062
(Publication Type: Journal Article, Review)
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Chemical References |
- CACNA1A protein, human
- Calcium Channels
- Calcium Channels, N-Type
- Calcium Channels, P-Type
- Calcium Channels, Q-Type
- voltage-dependent calcium channel (P-Q type)
- ATP1A2 protein, human
- Sodium-Potassium-Exchanging ATPase
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Topics |
- Calcium Channels
(metabolism)
- Calcium Channels, N-Type
- Calcium Channels, P-Type
- Calcium Channels, Q-Type
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 19
- Genes, Dominant
- Genetic Linkage
- Genetic Predisposition to Disease
- Headache
- Humans
- Migraine Disorders
(etiology, genetics)
- Migraine with Aura
(diagnosis, genetics, physiopathology)
- Models, Genetic
- Mutation
- Sodium-Potassium-Exchanging ATPase
(metabolism)
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