Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Recent studies suggest that scavenger receptor BI function is not only crucial for cholesterol delivery to the liver but is also important for cholesterol efflux at the vessel wall. Therefore, the receptor acts at both ends of the reverse cholesterol transport pathway. In addition, it stimulates nitric oxide production in endothelial cells, which may also contribute to its positive influence on the vasculature. Lastly, the glycoprotein was cloned as a scavenger receptor and in some cases is still thought to operate in this fashion. SUMMARY:
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Authors | Margery A Connelly, David L Williams |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 15
Issue 3
Pg. 287-95
(Jun 2004)
ISSN: 0957-9672 [Print] England |
PMID | 15166784
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- CD36 Antigens
- Lipoproteins, HDL
- Receptors, Immunologic
- Receptors, Lipoprotein
- Receptors, Scavenger
- high density lipoprotein receptors
- Cholesterol
|
Topics |
- Animals
- Arteriosclerosis
(metabolism)
- Biological Transport
- CD36 Antigens
(metabolism)
- Cardiovascular Diseases
(metabolism)
- Cholesterol
(metabolism)
- Humans
- Lipoproteins, HDL
(metabolism)
- Receptors, Immunologic
(metabolism)
- Receptors, Lipoprotein
(metabolism)
- Receptors, Scavenger
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