New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.

Abstract

Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.

• Authors: Yong-Hong Wang, Ai-Jun Hou, Lei Chen, Dao-Feng Chen, Han-Dong Sun, Qin-Shi Zhao, Kenneth F Bastow, Yuka Nakanish, Xi-Hong Wang, Kuo-Hsiung Lee
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 5 Pg. 757-61 (May 2004) ISSN: 0163-3864 [Print] United States
• PMID: 15165133 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Flavonoids

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Artocarpus (chemistry)
• Drug Resistance, Neoplasm (drug effects)
• Drug Screening Assays, Antitumor
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Humans
• Molecular Structure
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Tumor Cells, Cultured