Cefetamet pivoxil in pediatric otitis media.

Abstract

Cefetamet, an oral 3rd-generation cephalosporin, was investigated in 40 children with acute otitis media in a comparative randomized trial. The efficacy of 20 mg/kg cefetamet syrup in 20 patients was compared with that of 20 mg/kg cefaclor in another 20, both drugs being given orally twice daily for 7 days. Tympanocentesis was performed for every child before the initiation of antimicrobial treatment. After 7 days treatment with cefetamet pivoxil, clinical cure was obtained in 12 patients, 3 were failures and 5 could not be assessed. In the cefaclor group, 10 patients were cured, 1 improved and 9 were failures. No severe adverse events were observed with either drug.

• Authors: J S Pukander, S H Paloheimo, M M Sipilä
• Journal: Chemotherapy (Chemotherapy) Vol. 38 Suppl 2 Pg. 25-8 ( 1992) ISSN: 0009-3157 [Print] Switzerland
• PMID: 1516461 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cefaclor
• Ceftizoxime
• cefetamet pivoxyl

Topics

• Acute Disease
• Administration, Oral
• Bacterial Infections (drug therapy)
• Cefaclor (administration & dosage, therapeutic use)
• Ceftizoxime (administration & dosage, analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Humans
• Infant
• Otitis Media (drug therapy)
• Treatment Outcome