It is a known fact that
ethanol increases
lipid levels in humans and experimental animals. In this study, we have investigated the effect of
dendrodoine analogue (DA), DA-[4-amino-5-benzoyl-2-(4-methoxyphenylamino)-
thiazole], on alcohol- and thermally oxidized
sunflower oil-induced
hyperlipidemia.
Ethanol was given to animals at a dose of 5 ml of 20%
solution and thermally oxidized
sunflower oil at a level of 15% (15 g oil/100 g feed). Our results showed increased activity of
aspartate transaminase (AST),
alkaline phosphatase (ALP) and gamma-glutamyl
transferase (GGT) and increased levels of
cholesterol,
triglycerides and
phospholipids in the plasma of groups given alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control group. The levels of tissue (liver and kidney)
cholesterol and
triglycerides were increased significantly in groups treated with alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats. The levels were decreased when DA was given along with alcohol and thermally oxidized oil. The level of
phospholipids decreased significantly in the liver and kidney of rats administered alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats. The level increased when DA was administered along with alcohol and thermally oxidized oil. The activity of
phospholipase A and C increased significantly in the liver of groups given alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats, whereas the activity was decreased upon DA treatment. The obtained results indicate that DA can decrease the
lipid levels in alcohol- and thermally oxidized oil-treated rats.