Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection.

Abstract

Numerous inflammatory cells are recruited in response to Cryptosporidium parvum infection. These cells include interferon gamma-producing T lymphocytes, which are of major importance for the resolution of infection. Here, we show that beta7 integrin is not essential for the control of infection in mice but that beta7-deficient neonatal mice are more susceptible during the early stages of infection.

• Authors: Roselyne Mancassola, Sonia Lacroix-Lamandé, Mathieu Barrier, Muriel Naciri, Henri Salmon, Fabrice Laurent
• Journal: Infection and immunity (Infect Immun) Vol. 72 Issue 6 Pg. 3634-7 (Jun 2004) ISSN: 0019-9567 [Print] United States
• PMID: 15155674 (Publication Type: Journal Article)

Chemical References

• Integrin beta Chains
• integrin beta7

Topics

• Animals
• Animals, Newborn
• Cattle
• Cryptosporidiosis (immunology, parasitology, physiopathology)
• Cryptosporidium parvum (pathogenicity)
• Disease Susceptibility
• Humans
• Ileum (immunology, parasitology)
• Integrin beta Chains (genetics, metabolism)
• Mice
• Mice, Inbred C57BL
• T-Lymphocytes (immunology)
• Time Factors