Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis.

Abstract	The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (P < 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (P < 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis.
Authors	Gloria M González, Rolando Tijerina, Laura K Najvar, Rosie Bocanegra, Michael G Rinaldi, John R Graybill
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 48 Issue 6 Pg. 2140-3 (Jun 2004) ISSN: 0066-4804 [Print] United States
PMID	15155212 (Publication Type: Comparative Study, Journal Article)
Chemical References	Antifungal Agents Colloids Drug Carriers Liposomes Amphotericin B
Topics	Amphotericin B (administration & dosage, therapeutic use) Animals Antifungal Agents (administration & dosage, therapeutic use) Coccidioides (drug effects) Coccidioidomycosis (drug therapy, microbiology) Colloids Colony Count, Microbial Drug Carriers Liposomes Liver (microbiology) Lung (microbiology) Mice Microbial Sensitivity Tests Spleen (microbiology) Survival Analysis

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