Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows.

Abstract

OBJECTIVE:

To evaluate the efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for treatment of acute postpartum metritis (APM) in dairy cows.

DESIGN:

Multilocation, randomized block, field trial.

ANIMALS:

406 cows in the first 14 days postpartum.

PROCEDURE:

Cows with rectal temperatures > or = 39.5 degrees C (103.1 degrees F) without clinical signs of respiratory or gastrointestinal tract disease and with a fetid vaginal discharge were allocated randomly in blocks of 3 to 3 treatment groups: sterile saline (0.9% NaCl) solution administered at a dosage of 2 mL/45.4 kg (2 mL/100 lb), SC or IM, once daily for 5 days (control); or ceftiofur hydrochloride administered at a dosage of 1.1 or 2.2 mg of ceftiofur equivalents (CE)/kg (0.5 or 1 mg/lb, respectively), SC or IM, once daily for 5 days. Cows were evaluated on days 6, 10, and 14, and clinical cure or failure to cure was determined. Clinical cure was defined as no additional antimicrobial treatment administered, rectal temperature < 39.5 degrees C, and absence of a fetid vaginal discharge.

RESULTS:

On day 14, clinical cure rates were 77%, 65%, and 62% for the 2.2 mg of CE/kg, 1.1 mg of CE/kg, and control groups, respectively. No significant differences were detected in clinical cure rates between control and treatment groups on day 10 or 6.

CONCLUSIONS AND CLINICAL RELEVANCE:

Ceftiofur hydrochloride administered at a dosage of 2.2 mg of CE/kg, SC or IM, once daily for 5 days was efficacious for treatment of APM in dairy cows.

• Authors: John R Chenault, Joseph F McAllister, S Theodore Chester Jr, Kenneth J Dame, Fabian M Kausche, Edward J Robb
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 224 Issue 10 Pg. 1634-9 (May 15 2004) ISSN: 0003-1488 [Print] United States
• PMID: 15154734 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Suspensions
• ceftiofur

Topics

• Animals
• Cattle
• Cattle Diseases (drug therapy)
• Cephalosporins (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Endometritis (drug therapy, veterinary)
• Female
• Injections, Intramuscular (veterinary)
• Injections, Subcutaneous (veterinary)
• Postpartum Period
• Pregnancy
• Random Allocation
• Suspensions
• Treatment Outcome
• Vaginal Discharge (drug therapy, veterinary)