Abstract | BACKGROUND: METHODS: Fifty-six patients who underwent heart transplantation from 1998 to 2002 at the Montreal Heart Institute were retrospectively analyzed. RESULTS: Six of 56 patients (11%) underwent CRRT after heart transplantation. Patients who underwent CRRT had lower preoperative creatinine clearance than those who did not (median 44 versus 59 mL/min, P=0.04) and lower first two-week postoperative creatinine clearance (median 23 versus 42 mL/min, P<0.01) compared with patients without CRRT. The total duration of CRRT ranged between two and 60 days (median 15 days). Cyclosporine was withheld for 12 days versus two days (P<0.01) and the time to achieve therapeutic levels of cyclosporine averaged 18 days versus nine days (P=0.01) among CRRT versus non-CRRT patients. Patients were administered thymoglobulin or basiliximab during cyclosporine withholding. The time to discharge from hospital after transplantation was longer in patients with CRRT (median 47 days versus 17 days, P<0.01). There was no mortality at three months in the CRRT group. CONCLUSION:
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Authors | Louis-Mathieu Stevens, Ismaïl El-Hamamsy, Martine Leblanc, Louis P Perrault, Michel Pellerin, Denis Bouchard, Michel Carrier, Canadian Hypertension Society |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
Vol. 20
Issue 6
Pg. 619-23
(May 01 2004)
ISSN: 0828-282X [Print] England |
PMID | 15152292
(Publication Type: Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Creatinine
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Topics |
- Acute Kidney Injury
(etiology, metabolism, therapy)
- Adult
- Creatinine
(metabolism)
- Female
- Heart Transplantation
(adverse effects)
- Hemodiafiltration
- Hemofiltration
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Length of Stay
- Male
- Middle Aged
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