Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: There was no statistical difference between the two groups in overall survival (primary efficacy end point) over the course of the study (median overall survival of 223 days versus 225 days; P = 0.65). However, a higher proportion of patients were alive at the end of the 15-week treatment phase in the chemotherapy plus SRL172 group (90%), than in the chemotherapy alone group (83%) (P = 0.061). At the end of the treatment phase, the response rate was 37% in the combined group and 33% in the chemotherapy alone group. Patients in the chemotherapy alone group had greater deterioration in their Global Health Status score (-14.3) than patients in the chemotherapy plus SRL172 group (-6.6) (P = 0.02). CONCLUSION: In this non-placebo controlled trial, SRL172 when added to standard cancer chemotherapy significantly improved patient quality of life without affecting overall survival times.
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Authors | M E R O'Brien, H Anderson, E Kaukel, K O'Byrne, M Pawlicki, J Von Pawel, M Reck, SR-ON-12 Study Group |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 15
Issue 6
Pg. 906-14
(Jun 2004)
ISSN: 0923-7534 [Print] England |
PMID | 15151947
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Vaccines
- Mitomycins
- SRL172
- Vinblastine
- Cisplatin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bacterial Vaccines
(immunology, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(immunology, therapy)
- Cisplatin
(therapeutic use)
- Female
- Humans
- Lung Neoplasms
(immunology, therapy)
- Male
- Middle Aged
- Mitomycins
(therapeutic use)
- Quality of Life
- Survival Analysis
- Treatment Outcome
- Vinblastine
(therapeutic use)
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