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[Effects of Shenshuai Yangzhen capsule on lipid metabolism disorder in rats with chronic renal failure].

AbstractOBJECTIVE:
To investigate the therapeutic effect of Shenshuai Yangzhen capsule, a preparation of traditional Chinese medicine, on lipid metabolism disorder in rats with chronic renal failure (CRF) and explore its mechanism.
METHODS:
Fifty male SD rats received 5/6 nephrectomy for preparation of CRF models and were randomized into CRF group, gemfibrozil group, high-, moderate- and low-dose Shenshuai Yangzhen groups, and normal control group. After 4-week treatment as indicated, myocardial lipoprotein lipase messenger RNA (LPL mRNA) level were measured by RT-PCR in rats with surgically induced renal failure (two-stage subtotal nephrectomy). The blood lipid parameters in CRF rats were also determined.
RESULTS:
Compared with those in the CRF group, the plasma total cholesterol, triglyceride, low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol concentrations in the treatment groups were significantly lower with substantially elevated plasma high-density lipoprotein cholesterol and LPL gene expression. No significant differences were noted between different dose groups of Shenshuai Yangzhen.
CONCLUSION:
Shenshuai Yangzhen capsule can regulate blood lipid levels in rats with renal insufficiency possibly by enhancing LPL gene expression.
AuthorsYu-ming Li, Lian-bo Wei, Gang Yuan, Zhi-gang Ma, Lin Huang
JournalDi 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 24 Issue 5 Pg. 549-52 (May 2004) ISSN: 1000-2588 [Print] China
PMID15151830 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Capsules
  • Drugs, Chinese Herbal
  • Lipids
  • RNA, Messenger
  • Lipoprotein Lipase
Topics
  • Animals
  • Capsules
  • Drugs, Chinese Herbal (pharmacology)
  • Kidney Failure, Chronic (metabolism)
  • Lipids (blood)
  • Lipoprotein Lipase (genetics)
  • Male
  • Myocardium (enzymology)
  • RNA, Messenger (analysis)
  • Rats
  • Rats, Sprague-Dawley

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