| Abstract | The efficacy of ertapenem 1 g once a day for the treatment of polymicrobial complicated intra-abdominal, complicated skin/skin-structure and acute pelvic infections was compared with piperacillin-tazobactam 3.375 g every 6 h in a post hoc analysis of data from three large randomized double-blind trials. Of the 1,558 treated patients in the three trials, no pathogen was identified in 345 (22.1%), 423 (27.2%) had a monomicrobial infection and 790 (50.7%) had a polymicrobial infection. At the test-of-cure assessment, there were no significant differences in outcome between the two treatment groups for any of the three infections. Cure rates (clinical and microbiological for intra-abdominal infection, clinical for skin/skin-structure and pelvic infections) in microbiologically evaluable patients for ertapenem and piperacillin-tazobactam, respectively, were 85.6% (154/180 evaluable patients) and 82.5% (127/154) for polymicrobial intra-abdominal infection, 80.3% (53/66) and 78.7% (48/61) for polymicrobial skin/skin-structure infection, and 95.7% (88/92) and 92.6% (88/95) for polymicrobial pelvic infection. Respective cure rates for all evaluable patients in the original trials were: 83.6% and 80.4% for intra-abdominal, 83.9% and 85.3% for skin/skin-structure, and 93.9% and 91.5% for pelvic infections. These data show that in the three trials, ertapenem 1 g once a day was highly effective for the treatment of polymicrobial infections and as effective as piperacillin-tazobactam 3.375 g every 6 h. |
| Authors | Joseph Solomkin, Hedy Teppler, Donald R Graham, Richard M Gesser, Anne R Meibohm, Subir Roy, Gail L Woods
(Affiliation: Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.)
|
| Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 53 Suppl 2
Pg. ii51-7
(Jun 2004)
ISSN: 0305-7453 England |
| PMID | 15150183
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Bacterial Agents
- Lactams
- beta-Lactams
- ertapenem
- piperacillin-tazobactam combination product
- Piperacillin
- Penicillanic Acid
|
| Topics |
- Abdomen
- Adolescent
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Bacteria, Aerobic
(isolation & purification)
- Bacteria, Anaerobic
(isolation & purification)
- Bacterial Infections
(complications, drug therapy, microbiology)
- Double-Blind Method
- Female
- Humans
- Lactams
(therapeutic use)
- Male
- Pelvic Infection
(drug therapy, microbiology)
- Penicillanic Acid
(analogs & derivatives, therapeutic use)
- Piperacillin
(therapeutic use)
- Prospective Studies
- Skin Diseases, Bacterial
(drug therapy, microbiology)
- Treatment Outcome
- beta-Lactams
|
