[Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].

Abstract

The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis: some animals survived, the others died in later periods. When the animals were infected with a pathogenetic strain of Clostridium difficile followed by exposure to lincomycin the use of eremomycin produced the similar effect.

• Authors: A A Rukhlina, L A Malkova, L A Shevniuk, T V Fomina, V M Bukhman, V M Koroleva, I N Bakulin, T I Sergeeva
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 37 Issue 3 Pg. 20-2 (Mar 1992) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Lechenie éremomitsinom antibiotikoassotsiirovannogo kolita zolotistykh khomiachkov.
• PMID: 1514862 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Glycopeptides
• eremomycin
• Lincomycin

Topics

• Administration, Oral
• Animals
• Anti-Bacterial Agents (therapeutic use)
• Clostridioides difficile (drug effects, pathogenicity)
• Cricetinae
• Disease Models, Animal
• Enterocolitis, Pseudomembranous (chemically induced, drug therapy, microbiology)
• Glycopeptides (therapeutic use)
• Injections, Intraperitoneal
• Lincomycin (administration & dosage, adverse effects)
• Male
• Mesocricetus
• Time Factors