Abstract | BACKGROUND: METHODS: We exposed groups of male and female rats and mice to air containing vapors of propylene glycol mono-t-butyl ether at concentrations of 75, 300, or 1,200 parts per million (ppm) for 6 hours per day, 5 days a week for 2 years. Untreated control animals were housed in similar exposure chambers but without chemical exposure for comparison. Tissues from more than 40 sites were examined for every animal. RESULTS: CONCLUSIONS:
|
Authors | National Toxicology Program |
Journal | National Toxicology Program technical report series
(Natl Toxicol Program Tech Rep Ser)
Issue 515
Pg. 1-306
(Mar 2004)
ISSN: 0888-8051 [Print] United States |
PMID | 15146215
(Publication Type: Journal Article)
|
Chemical References |
- Propylene Glycols
- Solvents
- propylene glycol mono-t-butyl ether
|
Topics |
- Administration, Inhalation
- Animals
- CHO Cells
(drug effects)
- Carcinogenicity Tests
- Cricetinae
- Cricetulus
- Erythrocytes
(drug effects)
- Female
- Kidney
(drug effects)
- Kidney Neoplasms
(chemically induced, pathology)
- Liver
(drug effects)
- Liver Neoplasms
(chemically induced, pathology)
- Male
- Mice
- Mice, Inbred Strains
- Mutagenicity Tests
- Propylene Glycols
(toxicity)
- Rats
- Rats, Inbred F344
- Salmonella typhimurium
(drug effects, genetics)
- Sex Factors
- Solvents
(toxicity)
|