HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The inhibitory effects of Silso-San-Gami on atherosclerosis in KHC rabbits.

Abstract
Silsosangami is a dried decoction of a mixture of seven Korean herbal medicines, consisting of Typhae pollen, Pteropi faeces, Paeoniae radicis rubra, Cnidii rhizoma, Persicae semen, Carthami flos, and Curcumae tuber. The inhibitory effect of this traditional herbal medicine, Silsosangami-water extract (SSG), on the progression of the atherosclerotic diseases was examined using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control group and a SSG-administrated group. In the control group, the area of atheromatous aortic plaques progressed between 4 weeks (30.43%) and 8 weeks (47.48%). This progressin of atherosclerotic disease was not observed in the SSG-treated group between 4 weeks (22.65%) and 8 weeks (23.23%). Antioxidative effects on LDL were observed in the SSG group at 12 and 14 weeks. SSG improved hypercholestrolemia in the KHC rabbits. These results suggest that SSG has inhibitory effects on the development of atheromatous plaques in spontaneous FH model rabbits. The antioxidative effects of SSG on LDL appear to be the source of the beneficial effects observed in this study.
AuthorsWon-Hwan Park, Sang-Seub Shin, Young-Choon Lee, Cheorl-Ho Kim
JournalThrombosis research (Thromb Res) Vol. 113 Issue 3-4 Pg. 235-41 ( 2004) ISSN: 0049-3848 [Print] United States
PMID15140588 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2004 Elsevier Ltd.
Chemical References
  • Antioxidants
  • Lipoproteins, LDL
  • Peptides
  • Plant Extracts
  • silsosangami
Topics
  • Amino Acid Sequence
  • Animals
  • Antioxidants (therapeutic use)
  • Aorta, Thoracic (drug effects, pathology)
  • Arteriosclerosis (blood, drug therapy, metabolism, pathology)
  • Chromatography, High Pressure Liquid
  • Disease Models, Animal
  • Hyperlipoproteinemia Type II (blood, drug therapy)
  • Lipoproteins, LDL (drug effects, metabolism)
  • Male
  • Peptides (chemistry)
  • Plant Extracts (chemistry, therapeutic use)
  • Rabbits
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: