Chemotherapy studies in autochthonous rat tumors intestinal cancer.

Abstract

Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N'-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.

• Authors: F Sych, M Habs, D Schmähl
• Journal: Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology (Z Krebsforsch Klin Onkol Cancer Res Clin Oncol) Vol. 92 Issue 1 Pg. 105-17 (Aug 24 1978) ISSN: 0084-5353 [Print] Germany
• PMID: 151400 (Publication Type: Journal Article)

Chemical References

• Dimethylhydrazines
• Methylnitronitrosoguanidine
• Doxorubicin
• Cyclophosphamide
• Dimethylnitrosamine
• Fluorouracil
• Methotrexate

Topics

• Adenocarcinoma (drug therapy)
• Animals
• Cyclophosphamide (therapeutic use)
• Dimethylhydrazines
• Dimethylnitrosamine (analogs & derivatives)
• Doxorubicin (therapeutic use)
• Drug Therapy, Combination
• Fluorouracil (therapeutic use)
• Gastrointestinal Neoplasms (chemically induced, drug therapy)
• Male
• Methotrexate (therapeutic use)
• Methylnitronitrosoguanidine
• Rats